According to the Glycemic Index Foundation, the Glycemic Index is a measure of how quickly carbohydrates are digested or broken down in the body.
Measured consumption of low GI foods or carbohydrates (with exercise) is essential for the control of diabetes, reducing the risk of heart disease and reducing cholesterol levels. They provide longer lasting energy and satisfy hunger for longer.
A Low GI diet will increase the body’s sensitivity to insulin. It forms part of a healthy diet, helping to lower and control weight, and leading to greater physical endurance and a general increase in your feeling of wellbeing.
Added to a high GI food, Phytolin™ can lower its GI level by slowing the rate of absorption of glucose into the blood stream.
Added to sugar it will result in a GI of less than 55.
Refined white sugar is 68-70.
HIGH GI >70
MEDIUM GI >56-69
LOW GI <55
Phytolin™ & High Antioxidants
Antioxidant levels are usually expressed in ORAC (oxygen radical absorbance capacity) “units” per gram of material or foodstuff. The ORAC “unit” is becoming the international standard for expressing the antioxidant power of foods and dietary supplements.
The natural polyphenols in Phytolin™ provide its antioxidant capability. In fact, Phytolin™ has a higher level of antioxidants than foods that contain polyphenols such as tea, red wine, fruits and berries.
Phytolin™ can be added as an ingredient to raise the antioxidant levels in a range of foods, beverages and pharmaceutical products. [Should we add cosmeceutical products link to Officinol???]
Inflammatory diseases such as diabetes and obesity are major issues in our society. Any intervention that reduces inflammation caused by cytokines released by inflamed cells, will have a positive outcome. Phytolin™ bio-actives have powerful anti-inflammatory properties that can reduce inflammatory cytokines.
Inflammation is a perfectly normal and beneficial process that occurs when your body’s white blood cells and chemicals protect you from foreign invaders like bacteria and viruses; it leads to trouble when the inflammatory response gets out of hand. Diet has a lot to do with this chain of events and products with Phytolin™ will assist.
Anti-inflammatory properties of Phytolin™ against cancer cell lines.
Cytokines are known to play pivotal roles in cancer initiation, progression and pathogenesis.
Human cancer cells are known to secrete an array of cytokines. The effects and changes of cytokines secreted by cancer cell lines were assessed with Phytolin™ presence. Changes in Th1/Th2 cytokines (proinflammatory and anti-inflammatory cytokines) determined – IL-2, IL-4, IL-6, IL-10, IL-8, IFN-g, TNF-a, GM-CSF, VEGF
Anti-inflammatory properties of Phytolin™ on inflammatory stimulated immune cells.
Monocyte / macrophage cell lines will be stimulated with LPS to induce an inflammatory profile.
The effects and changes of the pro-inflammatory profile of monocytes / macrophages assessed in the presence of phytolin™. Changes in Th1/Th2 cytokines (pro-inflammatory and anti-inflammatory cytokines) determined– IL-2, IL-4, IL-6, IL-10, IL-8, IFN-g, TNF-a, GM-CSF, VEGF. In addition, cell surface markers, indicating activation (inflammatory state) of monocytes / macrophage lines, such as, CD40, CD80, CD86, MHC class I, MHC class II, determined in the presence of Phytolin™.
Tumor Necrosis factor (TNF-α) is a proinflammatory cytokine that triggers downstream cellular feedback loops governing inflammation. TNF-α inhibitors are important anti-inflammatory agents that that have potential treatment for rheumatoid arthritis (RA) and other inflammatory diseases.
The purified Phytolin sample was tested as an anti-inflammatory agent by its ability to inhibit the expression of TNF-αin human cells.
Nuclear Factor ĸ B, (NF-ĸ B) is a protein complex that is involved in cellular responses to stimuli such as stress and free radicals, ultraviolet radiation, oxidized LDL and bacterial and viral antigens. It plays a key role in regulating the immune response to infection. Suppression of NF-ĸ B limits the production of proinflammatory gene expression and reduces the level of inflammation.
Anti-proliferative properties of Phytolin™ against cancer cell lines.
Human cancer cell lines of breast, colon, prostate and lung have been cultured in the presence of a dose range of Phytolin™ and anti-proliferative effects assessed over 1-7 days using MTT assays.
In addition, toxicity evaluated on cancer cell lines in the dose range of Phytolin™.
The purified Phytolin™ sample was tested as an anti-inflammatory agent on expression/production level of NF ĸ B in human cells.
Phytolin™ rich in natural polyphenols may be even more potent than aspirin and ibrufen as a non‑steroidal anti‑inflammatory product which may be added to food products.