PHYTOLIN™

Made by Nature, Proven by Science, the phyto-nutrients and anti-oxidant properties of Phytolin™ combine to provide a healthier option that slows down digestion and helps manage blood glucose levels.  Phytolin™ is also high in Polyphenols, which in general can provide key health benefits including reducing obesity, preventing the onset of Type II diabetes, reducing blood cholesterol plus assisting in weight control and loss.

As a globally patented, natural plant extract from Saccharum officinarum (Sugarcane), Phytolin™ is a light straw to dark golden coloured liquid, offering a sweet non-astringent flavour with slight treacle notes. It is a ‘clean label’ ingredient that is processed through our unique, in-house extraction facility, and is free from particulate or fibrous matter.

Bioavailable & Safe

Phytolin™ bioactives are known to scavenge all of the six key Reactive Oxygen Species (ROS).  ROS affect all cells and organs in the body.  TPM is one of the first companies to use Oxygen Radical Absorbance Capacity (ORAC 6.0) to explain this property.  Going hand in hand with ORAC 6.0, TPM carried out a further in-vivo test called Cellular Anti-oxidant Activity (CAA) which shows that Phytolin™ bioactives are bioavailable and safe.

Commercial Uses

Phytolin™ can be added to the production of a wide range of commercial beverages and foods with minimal changes to existing formulation and taste. To give your commercial food or beverage line a healthy, marketable point of difference, speak with our bioactive division today.

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Speak to a Phytolin™ expert in your region

According to the Glycemic Index Foundation, the Glycemic Index is a measure of how quickly carbohydrates are digested or broken down in the body.

Measured consumption of low GI foods or carbohydrates (with exercise) is essential for the control of diabetes, reducing the risk of heart disease and reducing cholesterol levels. They provide longer lasting energy and satisfy hunger for longer.

A Low GI diet will increase the body’s sensitivity to insulin. It forms part of a healthy diet, helping to lower and control weight, and leading to greater physical endurance and a general increase in your feeling of wellbeing.

Added to a high GI food, Phytolin™ can lower its GI level by slowing the rate of absorption of glucose into the blood stream.

Added to sugar it will result in a GI of less than 55.

Refined white sugar is 68-70.

HIGH GI  >70

MEDIUM GI >56-69

LOW GI <55

 

Phytolin™ & High Antioxidants

Anti-oxidant levels are usually expressed in ORAC (oxygen radical absorbance capacity) “units” per gram of material or foodstuff. The ORAC “unit” is becoming the international standard for expressing the antioxidant power of foods and dietary supplements.

The natural polyphenols in Phytolin™ provide its anti-oxidant capability.  In fact, Phytolin™ has a higher level of anti-oxidants than foods that contain polyphenols such as tea, red wine, fruits and berries.

Phytolin™ can be added as an ingredient to raise the anti-oxidant levels in a range of foods, beverages and pharmaceutical products. 

Anti-inflammatory

Inflammatory diseases such as diabetes and obesity are major issues in our society. Any intervention that reduces inflammation caused by cytokines released by inflamed cells, will have a positive outcome. Phytolin™ bio-actives have powerful anti-inflammatory properties that can reduce inflammatory cytokines.

Inflammation is a perfectly normal and beneficial process that occurs when your body’s white blood cells and chemicals protect you from foreign invaders like bacteria and viruses; it leads to trouble when the inflammatory response gets out of hand. Diet has a lot to do with this chain of events and products with Phytolin™ will assist.

Anti-inflammatory properties of Phytolin™ against cancer cell lines.

Cytokines are known to play pivotal roles in cancer initiation, progression and pathogenesis.
Human cancer cells are known to secrete an array of cytokines. The effects and changes of cytokines secreted by cancer cell lines were assessed with Phytolin™ presence. Changes in Th1/Th2 cytokines (proinflammatory and anti-inflammatory cytokines) determined – IL-2, IL-4, IL-6, IL-10, IL-8, IFN-g, TNF-a, GM-CSF, VEGF

Anti-inflammatory properties of Phytolin™ on inflammatory stimulated immune cells.

Monocyte / macrophage cell lines will be stimulated with LPS to induce an inflammatory profile.
The effects and changes of the pro-inflammatory profile of monocytes/macrophages assessed in the presence of phytolin™. Changes in Th1/Th2 cytokines (pro-inflammatory and anti-inflammatory cytokines) determined– IL-2, IL-4, IL-6, IL-10, IL-8, IFN-g, TNF-a, GM-CSF, VEGF. In addition, cell surface markers, indicating activation (inflammatory state) of monocytes/macrophage lines, such as, CD40, CD80, CD86, MHC class I, MHC class II, determined in the presence of Phytolin™.

Tumor Necrosis factor (TNF-α) is a proinflammatory cytokine that triggers downstream cellular feedback loops governing inflammation. TNF-α inhibitors are important anti-inflammatory agents that that have potential treatment for rheumatoid arthritis (RA) and other inflammatory diseases.

The purified Phytolin™ sample was tested as an anti-inflammatory agent by its ability to inhibit the expression of TNF-αin human cells.

Nuclear Factor ĸ B, (NF-ĸ B) is a protein complex that is involved in cellular responses to stimuli such as stress and free radicals, ultraviolet radiation, oxidized LDL and bacterial and viral antigens. It plays a key role in regulating the immune response to infection. Suppression of NF-ĸ B limits the production of pro-inflammatory gene expression and reduces the level of inflammation.

Anti-proliferative properties of Phytolin™ against cancer cell lines.

Human cancer cell lines of breast, colon, prostate and lung have been cultured in the presence of a dose range of Phytolin™ and anti-proliferative effects assessed over 1-7 days using MTT assays.
In addition, toxicity evaluated on cancer cell lines in the dose range of Phytolin™.
The purified Phytolin™ sample was tested as an anti-inflammatory agent on expression/production level of NF ĸ B in human cells.

Phytolin™ rich in natural polyphenols may be even more potent than aspirin and ibrufen as a non‑steroidal anti‑inflammatory product which may be added to food products.

TPM Patents (Family)

1. Use of sugar cane extracts in the treatment or prevention of microbial infections and dysbiosis (no family name)
2. Sugar cane extracts for use in animal feeds (Polygain family)
3. Improving the taste of consumables (No family name)
4. Use of polyphenol containing sugar cane extracts for preventing, improving or treating a skin condition (No family name)
5. Sugar cane derived extracts and methods of treatment (Diabetes treatment family)
6. Substances having body mass redistribution properties (BMR family)
7. Natural preservatives and antimicrobial agents (Natural preservative family)
8. Sugar extract (Polynol family)
9. Natural sweetener (Natural sweetener family)
10. Extracts derived from sugar cane and a process for their manufacture (Benecarb family)
11. Extraction method (Phytolin family)