Inflammatory diseases such as diabetes and obesity are major issues in our society and any intervention that reduces inflammation caused by cytokines released by inflamed cells will have a positive outcome to all concerned.
Phytolin™ bio-actives have powerful anti-inflammatory properties that can reduce inflammatory cytokines.
It’s important to realize that chronic inflammation is the source of many if not most diseases with excessive chronic levels of inflammatory markers in body cells are the cause of these diseases such as cardio vascular disease, cancer, diabetes, obesity and degenerative conditions like arthritis, joint pain and dementia.
Phytolin™ bio-actives can therefore target a wide range of conditions that are part of Metabolic Syndrome.
There is a new wave of consumers looking at "anti-inflammatory" foods, diets and ingredients with Phytolin™ as a product that is at the forefront of this emerging trend.
Inflammation is also perfectly normal and beneficial process that occurs when your body's white blood cells and chemicals protect you from foreign invaders like bacteria and viruses; it leads to trouble when the inflammatory response gets out of hand. Diet has a lot to do with this chain of events and products with Phytolin™ will assist.
Anti-inflammatory ingredients available from a number of foods that are well-known for their anti-inflammatory properties and with Phytolin™ natural extracts added ensure eating a wide variety of products on a regular basis can go a long way toward preventing chronic illness.
Diet a key for reducing chronic inflammation. Dietary components can either prevent or trigger inflammation from taking root in your body, and processed foods do the latter, courtesy of pro‑inflammatory ingredients like high fructose corn syrup, soy, processed vegetable oils (trans fats), and other chemical additives. Besides adding anti-inflammatory foods with Phytolin™ to the diet, avoid pro‑inflammatory dietary culprits such as refined sugar, processed fructose, and some grains to optimize insulin level, as insulin resistance this is a primary driver of chronic inflammation. Restricting total fructose intake should be less than 25 grams per day for insulin or leptin resistant for people with high blood pressure, high cholesterol, heart disease, or are overweight.
Avoid oxidized cholesterol (cholesterol that has gone rancid, such as that from overcooked, scrambled eggs). Foods cooked at high temperatures, especially if cooked with vegetable oil (such as peanut, corn, and soy oil).
Trans fats, replacing processed foods with whole, ideally organic foods will automatically address most of these factors, especially eating a large portion of your food raw.
Anti inflammatory properties of Phytolin™ against cancer cell lines.
Cytokines are known to play pivotal roles in cancer initiation, progression and pathogenesis.
Human cancer cells are known to secrete an array of cytokines. The effects and changes of cytokines secreted by cancer cell lines were assessed with Phytolin™ presence. Changes in Th1/Th2 cytokines (proinflammatory and anti-inflammatory cytokines) determined – IL-2, IL-4, IL-6, IL-10, IL-8, IFN-g, TNF-a, GM-CSF, VEGF
Anti inflammatory properties of phytolin™ on inflammatory stimulated immune cells.
Monocyte / macrophage cell lines will be stimulated with LPS to induce an inflammatory profile.
The effects and changes of the pro-inflammatory profile of monocytes / macrophages assessed in the presence of phytolin™. Changes in Th1/Th2 cytokines (pro-inflammatory and anti-inflammatory cytokines) determined– IL-2, IL-4, IL-6, IL-10, IL-8, IFN-g, TNF-a, GM-CSF, VEGF. In addition, cell surface markers, indicating activation (inflammatory state) of monocytes / macrophage lines, such as, CD40, CD80, CD86, MHC class I, MHC class II, determined in the presence of phytolin.
Tumor Necrosis factor (TNF-α) is a proinflammatory cytokine that triggers downstream cellular feedback loops governing inflammation. TNF-α inhibitors are important anti-inflammatory agents that that have potential treatment for rheumatoid arthritis (RA) and other inflammatory diseases.
The purified Phytolin sample was tested as an anti-inflammatory agent by its ability to inhibit the expression of TNF-αin human cells.
Nuclear Factor ĸ B, (NF-ĸ B) is a protein complex that is involved in cellular responses to stimuli such as stress and free radicals, ultraviolet radiation, oxidized LDL and bacterial and viral antigens. It plays a key role in regulating the immune response to infection. Suppression of NF-ĸ B limits the production of proinflammatory gene expression and reduces the level of inflammation.
Anti proliferative properties of phytolin™ against cancer cell lines.
Human cancer cell lines of breast, colon, prostate and lung have been cultured in the presence of a dose range of phytolin™ and anti-proliferative effects assessed over 1-7 days using MTT assays.
In addition, toxicity evaluated on cancer cell lines in the dose range of Phytolin.
The purified Phytolin™ sample was tested as an anti-inflammatory agent on expression/production level of NF ĸ B in human cells.
Phytolin™ rich in natural polyphenols may be even more potent than aspirin and ibrufen as a non‑steroidal anti‑inflammatory product which may be added to food products.